Acetone → 2-Hydroxy-4-(trifluoromethyl)benzaldehyde

HRID 1816565Notes

Reaction equation

HRID 1816565 reaction equation
COC[C:4]1([CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH2:7]1)C=O.Cl.[OH2:17].C[C:19](C)=[O:20]>>[OH:17][C:4]1[CH:7]=[C:8]([C:12]([F:13])([F:14])[F:15])[CH:9]=[CH:10][C:11]=1[CH:19]=[O:20]

Participants

5

Reactant 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 962WaterHCID 22494069HCID 22494069, compound

Product 1

HCID 224939012-Hydroxy-4-(trifluoromethyl)benzaldehyde

Procedure

5.0 g of 1-(methoxymethyl)-3-(trifluoromethyl)benzaldehyde was dissolved in 25 ml acetone, and 22 ml of 6 N hydrochloric acid was added. The mixture was reacted at room temperature for 3 hours, and water was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evapaorated, to give 4.5 g of 2-hydroxy-4-(trifluoromethyl)benzaldehyde as a pale reddish orange oil.

Workup

  1. customThe mixture was reacted at room temperature for 3 hours
  2. extractionby extracting with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate

Sources & evidence

ORD record
ord-8ed5a0d95cfc4bbaa7ed30a69bdb45f9
Source dataset
uspto-grants-2005_04
Patent number
US06884821B1

Reaction notes

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