2-Methoxy-4-(trifluoromethyl)benzoic acid → 2-[4-Methoxy-3-({[2-methoxy-4-(trifluoromethyl)benzoyl]amino}methyl)benzyl]butanoic acid
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=O.[NH2:16][CH2:17][C:18]1[CH:19]=[C:20]([CH:30]=[CH:31][C:32]=1[O:33][CH3:34])[CH2:21][CH:22]([CH2:28][CH3:29])[C:23]([O:25]CC)=[O:24]>>[CH3:34][O:33][C:32]1[CH:31]=[CH:30][C:20]([CH2:21][CH:22]([CH2:28][CH3:29])[C:23]([OH:25])=[O:24])=[CH:19][C:18]=1[CH2:17][NH:16][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([C:12]([F:15])([F:14])[F:13])=[CH:11][C:3]=1[O:2][CH3:1]Participants
3
Procedure
0.24 g of 2-methoxy-4-(trifluoromethyl)benzoic acid and 0.3 g of ethyl 2-[3-(aminomethyl)-4-methoxybenzyl]butanoate were treated in the same manners as in Example 19d) and then in Example 19e), to give 0.3 g of 2-[4-methoxy-3-({[2-methoxy-4-(trifluoromethyl)benzoyl]amino}methyl)benzyl]butanoic acid as a pale yellow oil.
Sources & evidence
- ORD record
- ord-365367140c5b4218bdf616ff58d19063
- Source dataset
- uspto-grants-2005_04
- Patent number
- US06884821B1
Reaction notes
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