反应详情

13.0 g of 2-methoxybenzylamine was dissolved in 80 ml tetrahydrofuran, and a solution of 16 g tertiary butyl dicarbonate in tetrahydrofuran (20 ml) was added. After the mixture was stirred at room temperature for 1 hour, the solvent was evaporated. The residue was dissolved in ethyl acetate and successively washed with 1N hydrochloricacid and brine. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was evaporated, to give 19.0 g of tertiary butyl N-(2-methoxybenzyl)carbamate was obtained.

1. customthe solvent was evaporated
2. dissolutionThe residue was dissolved in ethyl acetate
3. washsuccessively washed with 1N hydrochloricacid and brine
4. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
5. customthe solvent was evaporated