反应详情

39.1 g of methyl 2-benzyloxy-5-formyl-benzoate was dissolved in 300 ml methanol. 60 ml trimethyl orthoformate and 2 g of p-toluenesulffonic acid were added thereto, followed by heating under reflux for 4 hours. After cooling to room temperature, 5 ml triethylamine was added thereto, and the mixture was evaporated. The residue was dissolved in ethyl acetate, successively washed with water and saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 39.08 g of methyl 2-(benzyloxy)-5-(dimethoxymethyl)benzoate.

1. temperatureby heating
2. temperatureunder reflux for 4 hours
3. customthe mixture was evaporated
4. dissolutionThe residue was dissolved in ethyl acetate
5. washsuccessively washed with water and saturated aqueous sodium bicarbonate solution
6. dry with materialdried over anhydrous magnesium sulfate
7. customthe solvent was evaporated