反应详情

0.3 g of methyl 2-bromo-5-methyl-1,3-thiazole-4-carboxylate and 0.2 g of 3-chlorophenylboric acid were dissolved in toluene, and 0.15 g of tetrakistriphenyl phosphine and 0.7 g of potassium carbonate were added. The reaction solution was heated under reflux for 4 hours in a nitrogen atmosphere. The reaction solution was cooled, filtered through Celite and evapoarated. The residue was purified by silica gel column chromatography, to give 0.2 g of methyl 2-(3-methylphenyl)-5-methyl-1,3-thiazole-4-carboxylate.

1. temperatureThe reaction solution was heated
2. temperatureunder reflux for 4 hours in a nitrogen atmosphere
3. temperatureThe reaction solution was cooled
4. filtrationfiltered through Celite
5. customThe residue was purified by silica gel column chromatography