2-Fluoro-4-(trifluoromethyl)benzyl alcohol → 3-[3-([2-Fluoro-4-(trifluoromethyl)benzyl]oxymethyl)-4-methoxyphenyl]-2-isopropoxypropanoic acid

HRID 1816637Notes

Reaction equation

HRID 1816637 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].Br[CH2:15][C:16]1[CH:17]=[C:18]([CH2:24][CH:25]([O:29][CH:30]([CH3:32])[CH3:31])[C:26]([O-:28])=[O:27])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>>[F:1][C:2]1[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=[CH:6][C:3]=1[CH2:4][O:5][CH2:15][C:16]1[CH:17]=[C:18]([CH2:24][CH:25]([O:29][CH:30]([CH3:32])[CH3:31])[C:26]([OH:28])=[O:27])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

Participants

3

Reactant 2

HCID 27375612-Fluoro-4-(trifluoromethyl)benzyl alcoholHCID 224938933-[3-(Bromomethyl)-4-methoxyphenyl]-2-isopropoxypropanoate

Product 1

HCID 224941793-[3-([2-Fluoro-4-(trifluoromethyl)benzyl]oxymethyl)-4-methoxyphenyl]-2-isopropoxypropanoic acid

Procedure

Using 2-fluoro-4-(trifluoromethyl)benzyl alcohol and 3-[3-(bromomethyl)-4-methoxyphenyl]-2-isopropoxypropanoate, 3-[3-([2-fluoro-4-(trifluoromethyl)benzyl]oxymethyl)-4-methoxyphenyl]-2-isopropoxypropanoic acid was obtained in the same method as in Example 247).

Sources & evidence

ORD record
ord-e4b6d02b14aa4421a760805dbb5ee91d
Source dataset
uspto-grants-2005_04
Patent number
US06884821B1

Reaction notes

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