2-Bromopyridine → HCID 22493988, compound

HRID 1816665Notes

Reaction equation

[CH:1]([O:4][CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([CH2:20][NH:21][C:22](=[O:38])[C:23]2[CH:28]=[CH:27][C:26](B3OC(C)(C)C(C)(C)O3)=[CH:25][CH:24]=2)[CH:13]=1)[C:6]([O:8]CC)=[O:7])([CH3:3])[CH3:2].Br[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=1>>[CH:1]([O:4][CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([CH2:20][NH:21][C:22](=[O:38])[C:23]2[CH:24]=[CH:25][C:26]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=3)=[CH:27][CH:28]=2)[CH:13]=1)[C:6]([OH:8])=[O:7])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 79732-Bromopyridine

HCID 22494140HCID 22494140, compound

Product 1

HCID 22493988HCID 22493988, compound

Procedure

Using ethyl 2-isopropoxy-3-[4-methoxy-3-([4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzoyl]aminomethyl)phenyl]propanoate and 2-bromopyridine, 2-isopropoxy-3-[4-methoxy-3-[([4-(2-pyridyl)benzoyl]amino)methyl]phenyl)propanoic acid was obtained in the same method as in Example 285).

Sources & evidence

ORD record: ord-775caf07b3024e2492d2a37d75a2b30f
Source dataset: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06884821B1

Reaction notes

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