p-Bromochlorobenzene → 3,4'-Dichloro[1,1'-biphenyl]-4-carboxylic acid

HRID 1816669Notes

Reaction equation

HRID 1816669 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10](B2OC(C)(C)C(C)(C)O2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].Br[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:11]=[C:10]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 7806p-BromochlorobenzeneHCID 22493932Methyl 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Product 1

HCID 224938663,4'-Dichloro[1,1'-biphenyl]-4-carboxylic acid

Procedure

Using methyl 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzoate and 4-bromochlorobenzene, 2-chloro-4-(4′-chlorophenyl)benzoic acid was obtained in the same method as in Production Example 292b).

Sources & evidence

ORD record
ord-5c1d93c9cafb4abd8b75f28cb1e2d181
Source dataset
uspto-grants-2005_04
Patent number
US06884821B1

Reaction notes

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