Sodium Hydroxide → HCID 22494755, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-methoxyheptyl-[4-(methoxycarbonyl)phenyl]sulfone (0.85 g) and 1N-aqueous sodium hydroxide (5 ml) in a mixture of ethanol (20 ml) and tetrahydrofuran (10 ml) was stirred at 80° C. for 5 hours. The reaction mixture was concentrated under reduced pressure and the residue was triturated with water. The solution was adjusted to pH 1.0 using diluted hydrochloric acid. The precipitates were collected by filtration, washed with water and dried in vacuo to give 7-methoxyheptyl-(4-carboxyphenyl)sulfone (0.8 g) white solid.

Provenance & Evidence