Sodium Hydroxide → HCID 22494755, compound

HRID 1816679Notes

Reaction equation

HRID 1816679 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([O:21]C)=[O:20])=[CH:15][CH:14]=1)(=[O:12])=[O:11].[OH-].[Na+]>C(O)C.O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][CH:14]=1)(=[O:12])=[O:11]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22494628HCID 22494628, compound

Product 1

HCID 22494755HCID 22494755, compoundYield 98.3%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 7-methoxyheptyl-[4-(methoxycarbonyl)phenyl]sulfone (0.85 g) and 1N-aqueous sodium hydroxide (5 ml) in a mixture of ethanol (20 ml) and tetrahydrofuran (10 ml) was stirred at 80° C. for 5 hours. The reaction mixture was concentrated under reduced pressure and the residue was triturated with water. The solution was adjusted to pH 1.0 using diluted hydrochloric acid. The precipitates were collected by filtration, washed with water and dried in vacuo to give 7-methoxyheptyl-(4-carboxyphenyl)sulfone (0.8 g) white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was triturated with water
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-3e576bee6ac047239eb7e5943f298ac2
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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