HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[5-[4-(6-Methoxyhexyloxy)phenyl]isoxazol-3-yl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[5-[4-(6-Methoxyhexyloxy)phenyl]isoxazol-3-yl]benzoic acid methyl ester | HCID 54392828 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[5-[4-(6-Methoxyhexyloxy)phenyl]isoxazol-3-yl]benzoic acid | HCID 22492919 | 99.8% |
Reaction Steps
To a solution of 4-[5-[4-(6-methoxyhexyloxy)phenyl]isoxazol-3-yl]benzoic acid methyl ester (1.0 g) in a mixture of ethanol (10 ml) and tetrahydrofuran (20 ml) was added 10% sodium hydroxide aqueous solution (4.4 ml) and refluxed for 1 hour. The reaction mixture was adjusted to pH 1-2 with 1N-hydrochloric acid, and the resulting precipitate was collected by filtration to give 4-[5-[4-(6-methoxyhexyloxy)phenyl]isoxazol-3-yl]benzoic acid (964.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06884868B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-32e6fd1b3fce4ac89cd74980912710ab |
| Source note | uspto-grants-2005_04 |