反应详情

To a solution of 4-[5-[4-(6-methoxyhexyloxy)phenyl]isoxazol-3-yl]benzoic acid methyl ester (1.0 g) in a mixture of ethanol (10 ml) and tetrahydrofuran (20 ml) was added 10% sodium hydroxide aqueous solution (4.4 ml) and refluxed for 1 hour. The reaction mixture was adjusted to pH 1-2 with 1N-hydrochloric acid, and the resulting precipitate was collected by filtration to give 4-[5-[4-(6-methoxyhexyloxy)phenyl]isoxazol-3-yl]benzoic acid (964.2 mg).

1. temperaturerefluxed for 1 hour
2. filtrationthe resulting precipitate was collected by filtration