HCID 22494651, compound → UUKHAODJZMXSOX-UHFFFAOYSA-N

HRID 1816701Notes

Reaction equation

HRID 1816701 reaction equation
[CH:1]1([O:7][CH:8]2[CH2:13][CH2:12][N:11](C(OCC3C=CC=CC=3)=O)[CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH:3]=[CH:2]1.[H][H]>[Pd].CO>[CH:1]1([O:7][CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 22494651HCID 22494651, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22494678UUKHAODJZMXSOX-UHFFFAOYSA-NYield 109.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-(2-cyclohexenyloxy)-N-(benzyloxycarbonyl)piperidine (3.80 g), and 10% palladium on carbon (50% wet) (1.0 g) in methanol (40 ml) was hydrogenated under an atmospheric pressure of hydrogen at ambient temperature for 6 hours. The catalyst was filtered off, and the filtrate was evaporated in vacua and dried in vacuo to give 4-(cyclohexyloxy)piperidine (2.42 g).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated in vacua
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e3b2890dae964cc2815a21600f6766dd
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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