反应详情

温度

75 °C

A mixture of 1-acetyl-4-[4-(6-methoxyhexyloxy)phenyl]piperazine (4.87 g) and 6N-hydrochloric acid (50 ml) was heated at 75° C. for 3 hours. After cooling, the solution was adjusted to pH 11 with 25% sodium hydroxide aqueous solution then the resulting precipitate was collected by filtration, washed with water and dried under reduced pressure to give 4-[4-(6-methoxyhexyloxy)phenyl]piperazine (3.77 g) as a pale brown solid.

1. temperatureAfter cooling
2. filtrationthe resulting precipitate was collected by filtration
3. washwashed with water
4. customdried under reduced pressure