Sodium Hydroxide → HCID 22494620, compound

HRID 1816718Notes

Reaction equation

HRID 1816718 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][CH3:24])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>Cl>[CH3:24][O:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22494712HCID 22494712, compound

Product 1

HCID 22494620HCID 22494620, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
75 °C

Procedure

A mixture of 1-acetyl-4-[4-(6-methoxyhexyloxy)phenyl]piperazine (4.87 g) and 6N-hydrochloric acid (50 ml) was heated at 75° C. for 3 hours. After cooling, the solution was adjusted to pH 11 with 25% sodium hydroxide aqueous solution then the resulting precipitate was collected by filtration, washed with water and dried under reduced pressure to give 4-[4-(6-methoxyhexyloxy)phenyl]piperazine (3.77 g) as a pale brown solid.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-55676cc2e8884d8eb57def767915cd5d
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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