1,4-Dioxane hydrochloride → HCID 22494746, compound

HRID 1816734Notes

Reaction equation

HRID 1816734 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][CH:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32].O1CCOCC1>O1CCOCC1>[ClH:32].[ClH:32].[ClH:32].[C:26]1([CH:23]2[CH2:22][CH2:21][N:20]([C:17]3[CH:18]=[CH:19][C:14]([N:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)=[CH:15][CH:16]=3)[CH2:25][CH2:24]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54063721HCID 54063721, compound

Product 1

HCID 22494746HCID 22494746, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-[4-(4-phenylpiperidin-1-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester (2.45 g) in 1,4-dioxane (62 ml) was added dropwise 4N-HCl/1,4-dioxane (58 ml) at ambient temperature. The reaction mixture was stirred for 110 minutes at ambient temperature, and stirred for 2 hours at 80° C. The precipitate was filtered and dried to give 1-[4-(4-phenylpiperidin-1-yl)phenyl]piperazine trihydrochloride salt (2.07 g).

Workup

  1. stirringstirred for 2 hours at 80° C
  2. filtrationThe precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-67e2210ad53e45e49a30a462aa2d8cf8
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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