1,4-Dioxane hydrochloride → HCID 22494746, compound

Participants

Reaction Steps

To a solution of 4-[4-(4-phenylpiperidin-1-yl)phenyl]piperazine-1-carboxylic acid tert-butyl ester (2.45 g) in 1,4-dioxane (62 ml) was added dropwise 4N-HCl/1,4-dioxane (58 ml) at ambient temperature. The reaction mixture was stirred for 110 minutes at ambient temperature, and stirred for 2 hours at 80° C. The precipitate was filtered and dried to give 1-[4-(4-phenylpiperidin-1-yl)phenyl]piperazine trihydrochloride salt (2.07 g).

Provenance & Evidence