Sodium Hydroxide → 1-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

HRID 1816741Notes

Reaction equation

HRID 1816741 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][C:19]([O:28][CH3:29])([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>C(O)C>[CH3:29][O:28][C:19]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:18][CH2:17][N:16]([C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)=[CH:15][CH:14]=2)[CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 224947141-Acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

Product 1

HCID 224946521-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazineYield 97.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.5 g) and 10% NaOH aq. (10.2 ml) in ethyl alcohol (50 ml) was refluxed for 23.5 hours. The reaction mixture was evaporated under reduced pressure. The residue was washed with water, and dried to give 1-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.18 g).

Workup

  1. temperaturewas refluxed for 23.5 hours
  2. customThe reaction mixture was evaporated under reduced pressure
  3. washThe residue was washed with water
  4. customdried

Sources & evidence

ORD record
ord-817354e23e2d4fe7b375eb987f56526b
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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