Sodium Hydroxide → 1-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	1-Acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine	HCID 22494714	—
Solvent	Ethanol	HCID 702	—
Product	1-[4-(4-Methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine	HCID 22494652	97.6%

Reaction Steps

A mixture of 1-acetyl-4-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.5 g) and 10% NaOH aq. (10.2 ml) in ethyl alcohol (50 ml) was refluxed for 23.5 hours. The reaction mixture was evaporated under reduced pressure. The residue was washed with water, and dried to give 1-[4-(4-methoxy-4-phenylpiperidin-1-yl)phenyl]piperazine (2.18 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06884868B1
Source dataset	uspto-grants-2005_04
ORD ID	ord-817354e23e2d4fe7b375eb987f56526b
Source note	uspto-grants-2005_04