Hydrogen chloride-ethyl acetate → HCID 22494753, compound

Participants

Reaction Steps

To a solution of 4-[4-[4-(4-chlorophenyl)-4-methoxypiperidin-1-yl]phenyl]piperazine-1-carboxylic acid tert-butyl ester (1.56 g) in ethyl acetate (62 ml) was added dropwise 4N-HCl/ethyl acetate (40 ml) at ambient temperature. The reaction mixture was stirred for 33 hours at ambient temperature. The precipitate was collected by filtration, and dried under reduced pressure to give 4-[4-[4-(4-chlorophenyl)-4-methoxypiperidin-1-yl]phenyl]piperazine trihydrochloride salt (1.52 g).

Provenance & Evidence