Hydrogen chloride-ethyl acetate → HCID 22494753, compound

HRID 1816746Notes

Reaction equation

HRID 1816746 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][C:23]([C:28]4[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=4)([O:26][CH3:27])[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:35].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:34].[ClH:35].[ClH:34].[Cl:34][C:31]1[CH:32]=[CH:33][C:28]([C:23]2([O:26][CH3:27])[CH2:24][CH2:25][N:20]([C:17]3[CH:16]=[CH:15][C:14]([N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[CH:19][CH:18]=3)[CH2:21][CH2:22]2)=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 54292562HCID 54292562, compound

Product 1

HCID 22494753HCID 22494753, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-[4-[4-(4-chlorophenyl)-4-methoxypiperidin-1-yl]phenyl]piperazine-1-carboxylic acid tert-butyl ester (1.56 g) in ethyl acetate (62 ml) was added dropwise 4N-HCl/ethyl acetate (40 ml) at ambient temperature. The reaction mixture was stirred for 33 hours at ambient temperature. The precipitate was collected by filtration, and dried under reduced pressure to give 4-[4-[4-(4-chlorophenyl)-4-methoxypiperidin-1-yl]phenyl]piperazine trihydrochloride salt (1.52 g).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-372bcdeab66e4617902a7e338ad5a02a
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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