Iodoethanol → HCID 22494727, compound

HRID 1816777Notes

Reaction equation

HRID 1816777 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[I:9][CH2:10][CH2:11][OH:12]>CN(C)C=O>[I-:9].[OH:12][CH2:11][CH2:10][N+:2]1([CH3:1])[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 12225IodoethanolHCID 740491-Methyl-4-piperidone

Product 1

HCID 22494727HCID 22494727, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 1-methyl-4-piperidone (1.0 g) in N,N-dimethylformamide (10 ml) was added 2-iodoethanol (0.70 ml-1.5 g) and stirred overnight at ambient temperature. The reaction mixture was evaporated under reduced pressure and washed by ethyl acetate to afford 1-(2-hydroxyethyl)-1-methyl-4-oxopiperidinium iodide (0.94 g).

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. washwashed by ethyl acetate

Sources & evidence

ORD record
ord-0029fa0a0c8a44b594f3136f55b49b7a
Source dataset
uspto-grants-2005_04
Patent number
US06884868B1

Reaction notes

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