HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-benzyl-6-fluoro-4-piperazin-1-yl-1H-indole-2-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 68585990 | HCID 68585990 | — |
| Reactant | HCID 68586272 | HCID 68586272 | — |
| Product | 1-benzyl-6-fluoro-4-piperazin-1-yl-1H-indole-2-carboxylic acid amide | HCID 24953071 | — |
| Product | HCID 68585990 | HCID 68585990 | — |
Reaction Steps
1-Benzyl-4-(4-tert-butoxycarbonyl-piperazin-1-yl)-6-fluoro-1H-indole-2-carboxylic acid amide was prepared from 1-benzyl-4-(4-tert-butoxycarbonyl-piperazin-1-yl)-6-fluoro-1H-indole-2-carboxylic acid using the procedure of step 4 of Example 1. The 1-benzyl-4-(4-tert-butoxycarbonyl-piperazin-1-yl)-6-fluoro-1H-indole-2-carboxylic acid amide was treated with ethanolic HCl as described in step 4 of Example 2 to give 1-benzyl-6-fluoro-4-piperazin-1-yl-1H-indole-2-carboxylic acid amide as a hydrochloride salt. MS: 353 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741326B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-23694764c3a9480b8a25fd2c26f2b924 |
| Source note | uspto-grants-2010_06 |