反应详情

1-Benzyl-4-(4-tert-butoxycarbonyl-piperazin-1-yl)-6-fluoro-1H-indole-2-carboxylic acid amide was prepared from 1-benzyl-4-(4-tert-butoxycarbonyl-piperazin-1-yl)-6-fluoro-1H-indole-2-carboxylic acid using the procedure of step 4 of Example 1. The 1-benzyl-4-(4-tert-butoxycarbonyl-piperazin-1-yl)-6-fluoro-1H-indole-2-carboxylic acid amide was treated with ethanolic HCl as described in step 4 of Example 2 to give 1-benzyl-6-fluoro-4-piperazin-1-yl-1H-indole-2-carboxylic acid amide as a hydrochloride salt. MS: 353 (M+H)+.