Bromoacetyl chloride → HCID 68864194, compound

HRID 1816896Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)[OH:10].[Br:21][CH2:22][C:23](Cl)=[O:24]>>[Br:21][CH2:22][C:23]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([OH:10])([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)[C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)=[O:24]

Participants

Reactant 2

HCID 89602Bromoacetyl chloride

HCID 68866291HCID 68866291, compound

Product 1

HCID 68864194HCID 68864194, compound

Procedure

Prepared from (2-amino-5-bromophenyl)(dithien-2-yl)methanol and bromoacetyl chloride using the procedure described in example 1. 1H-NMR (DMSO-d6) δ 10.22 (s, 1H), 8.42 (s, 1H), 8.05 (d, J=9.0 Hz, 1H) 7.59 (m, 3H), 7.05 (m, 2H), 6.87 (m, 2H), 6.78 (d, J=3 Hz, 1H), 3.92 (s, 2H); MS (ES) m/z 484 (M−H)−.

Sources & evidence

ORD record: ord-0754dff38c2f445d8aadbcb31972e151
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598237B2

Reaction notes

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