Hydrochloric Acid → Ethyl 3-piperidin-4-ylbenzoate hydrochloride

HRID 1816970노트

반응식

HRID 1816970 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[CH:9]=[CH:10][CH:11]=1)=[O:5])[CH3:2].[ClH:25]>O1CCOCC1>[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12]([C:8]2[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=2)[C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:13][CH2:14]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57880576Tert-butyl 4-[3-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate

생성물 1

HCID 66973363Ethyl 3-piperidin-4-ylbenzoate hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

tert-Butyl 4-[3-(ethoxycarbonyl)phenyl]piperidine-1-carboxylate (3.24 g, 9.72 mmol) was dissolved in anhydrous 4N HCl in dioxane (ca. 30 mL) and stirred at rt for 1.5 h. The reaction mixture was concentrated to give ethyl 3-piperidin-4-ylbenzoate hydrochloride as a pale yellow solid that required no further purification.

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-00940cff5f4e43ac8f3ee23bc6c0d8b9
출처 데이터셋
uspto-grants-2009_10
특허 번호
US07598243B2

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