Triethylamine → HCID 21106441, compound

HRID 1817113Notes

Reaction equation

HRID 1817113 reaction equation
[C:1]1([NH:7][C:8]2[N:9]=[N:10]NC=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:14]1[CH:19]=[C:18]([Cl:20])[N:17]=[CH:16][N:15]=1.[CH2:21]([N:23](CC)CC)C>C(#N)C>[Cl:20][C:18]1[N:17]=[CH:16][N:15]=[C:14]([N:10]2[CH:21]=[N:23][C:8]([NH:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:9]2)[CH:19]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 709434,6-DichloropyrimidineHCID 178420479HCID 178420479, compound

Product 1

HCID 21106441HCID 21106441, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of phenylaminotriazole (3.12 mmol), 4,6-dichloropyrimidine (4.1 mmol, 1.3 equivalents) and triethylamine (4.7 mmol, 1.5 equivalents) in acetonitrile (20 ml) was stirred at reflux for eighteen hours. The reaction mixture was partitioned between ethyl acetate and brine. A white precipitate formed and was removed by filtration to afford the title compound which was used without purification in the next step. LC-MS: [MH+] 274.

Workup

  1. temperatureat reflux for eighteen hours
  2. customThe reaction mixture was partitioned between ethyl acetate and brine
  3. customA white precipitate formed
  4. customwas removed by filtration

Sources & evidence

ORD record
ord-ec43bc5b8833482391c920df13af2e2f
Source dataset
uspto-grants-2009_10
Patent number
US07598245B2

Reaction notes

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