反应详情

To a solution of 2,4,6-trimethoxystyryl-3-amino-4-methoxybenzylsulfone (10 mmol) in methanol (40 mL) is added 4-nitrobenzaldehyde (10 mmol). The solution is refluxed with vigorous stirring for 5 h. The reaction mixture is cooled, diluted with water and the aqueous mixture is then extracted twice with dichloromethane and organic layer is dried over anhydrous magnesium sulfate. The dried organic solution is evaporated and the residue is recrystallized to give (E)-2,4,6-trimethoxystyryl-3-(4-nitrophenylimino)-4-methoxybenzylsulfone.

1. temperatureThe solution is refluxed
2. temperatureThe reaction mixture is cooled
3. extractionthe aqueous mixture is then extracted twice with dichloromethane and organic layer
4. dry with materialis dried over anhydrous magnesium sulfate
5. customThe dried organic solution is evaporated
6. customthe residue is recrystallized