Potassium Carbonate → HCID 86598620, compound

HRID 1817140Notes

Reaction equation

HRID 1817140 reaction equation
[CH3:1][O:2][C:3]1[CH:63]=[C:62]([O:64][CH3:65])[CH:61]=[C:60]([O:66][CH3:67])[C:4]=1/[CH:5]=[CH:6]/[CH:7]([S:25]([CH:28](/[CH:46]=[CH:47]/[C:48]1[C:53]([O:54][CH3:55])=[CH:52][C:51]([O:56][CH3:57])=[CH:50][C:49]=1[O:58][CH3:59])[C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([NH:37][C:38](=[O:45])[CH:39]([O:41]C(=O)C)[CH3:40])[CH:30]=1)(=[O:27])=[O:26])[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([NH:16][C:17](=[O:24])[CH:18]([O:20]C(=O)C)[CH3:19])[CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C.O>[CH3:55][O:54][C:53]1[CH:52]=[C:51]([O:56][CH3:57])[CH:50]=[C:49]([O:58][CH3:59])[C:48]=1/[CH:47]=[CH:46]/[CH:28]([S:25]([CH:7](/[CH:6]=[CH:5]/[C:4]1[C:3]([O:2][CH3:1])=[CH:63][C:62]([O:64][CH3:65])=[CH:61][C:60]=1[O:66][CH3:67])[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([NH:16][C:17](=[O:24])[CH:18]([CH3:19])[OH:20])[CH:9]=1)(=[O:26])=[O:27])[C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([NH:37][C:38](=[O:45])[CH:39]([OH:41])[CH3:40])[CH:30]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86598621HCID 86598621, compound

Product 1

HCID 86598620HCID 86598620, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A solution of (E)-2,4,6-trimethoxystyryl-3-(2-acetoxypropionamido)-4-methoxybenzylsulfone (10 mmol) was hydrolyzed with potassium carbonate (70 mmol) in 1:1 ethanol/water (25 mL) to give (E)-2,4,6-trimethoxystyryl-3-(2-hydroxy-2-methylacetamido)-4-methoxy benzylsulfone. (m.p. 174-1 76° C.)

Sources & evidence

ORD record
ord-436e61ffd31d4d31be9190f064e635eb
Source dataset
uspto-grants-2009_10
Patent number
US07598232B2

Reaction notes

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