2-Acetoxypropionyl Chloride → HCID 86598621, compound

HRID 1817145Notes

Reaction equation

HRID 1817145 reaction equation
[C:1]([O:4][CH:5]([CH3:9])[C:6](Cl)=[O:7])(=[O:3])[CH3:2].[CH3:10][O:11][C:12]1[CH:56]=[C:55]([O:57][CH3:58])[CH:54]=[C:53]([O:59][CH3:60])[C:13]=1/[CH:14]=[CH:15]/[CH:16]([S:26]([CH:29](/[CH:39]=[CH:40]/[C:41]1[C:46]([O:47][CH3:48])=[CH:45][C:44]([O:49][CH3:50])=[CH:43][C:42]=1[O:51][CH3:52])[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32]([NH2:38])[CH:31]=1)(=[O:28])=[O:27])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([NH2:25])[CH:18]=1>>[CH3:60][O:59][C:53]1[CH:54]=[C:55]([O:57][CH3:58])[CH:56]=[C:12]([O:11][CH3:10])[C:13]=1/[CH:14]=[CH:15]/[CH:16]([S:26]([CH:29](/[CH:39]=[CH:40]/[C:41]1[C:42]([O:51][CH3:52])=[CH:43][C:44]([O:49][CH3:50])=[CH:45][C:46]=1[O:47][CH3:48])[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32]([NH:38][C:6](=[O:7])[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH3:9])[CH:31]=1)(=[O:28])=[O:27])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([NH:25][C:6](=[O:7])[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH3:9])[CH:18]=1

Participants

3

Reactant 2

HCID 45474922-Acetoxypropionyl ChlorideHCID 67401517HCID 67401517, compound

Product 1

HCID 86598621HCID 86598621, compoundYield 68.2%

Procedure

A solution of 2-acetoxypropionyl chloride (10 mmol) and (E)-2,4,6-trimethoxystyryl-3-amino-4-methoxybenzylsulfone (10 mmol) was reacted according to General Method A. The product obtained was purified by column chromatography to give the desired product in 68.2% yield. (m.p. 179-180° C.)

Workup

  1. customThe product obtained
  2. customwas purified by column chromatography

Sources & evidence

ORD record
ord-d85c05393da54c628a2504d48ae22f5b
Source dataset
uspto-grants-2009_10
Patent number
US07598232B2

Reaction notes

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