HCID 66912535, compound → HCID 131727648, compound

HRID 1817146Notes

Reaction equation

HRID 1817146 reaction equation
[CH3:1][N:2]([C:4]([F:9])([F:8])[C:5](Cl)=[O:6])[CH3:3].[CH3:10][O:11][C:12]1[CH:56]=[C:55]([O:57][CH3:58])[CH:54]=[C:53]([O:59][CH3:60])[C:13]=1[CH:14]=[CH:15][CH:16]([S:26]([CH:29]([CH:39]=[CH:40][C:41]1[C:46]([O:47][CH3:48])=[CH:45][C:44]([O:49][CH3:50])=[CH:43][C:42]=1[O:51][CH3:52])[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32]([NH2:38])[CH:31]=1)(=[O:28])=[O:27])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([NH2:25])[CH:18]=1>O1CCCC1>[CH3:60][O:59][C:53]1[CH:54]=[C:55]([O:57][CH3:58])[CH:56]=[C:12]([O:11][CH3:10])[C:13]=1/[CH:14]=[CH:15]/[CH:16]([S:26]([CH:29](/[CH:39]=[CH:40]/[C:41]1[C:42]([O:51][CH3:52])=[CH:43][C:44]([O:49][CH3:50])=[CH:45][C:46]=1[O:47][CH3:48])[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32]([NH:38][C:5](=[O:6])[C:4]([F:9])([F:8])[N:2]([CH3:3])[CH3:1])[CH:31]=1)(=[O:28])=[O:27])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([NH:25][C:5](=[O:6])[C:4]([N:2]([CH3:3])[CH3:1])([F:9])[F:8])[CH:18]=1

Participants

4

Reactant 2

HCID 66912535HCID 66912535, compoundHCID 85860995HCID 85860995, compound

Product 1

HCID 131727648HCID 131727648, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of dimethylamino-α,α-difluoroacetyl chloride (10 mmol) in tetrahydrofuran (40 mL) is added dropwise a solution of 2,4,6-trimethoxystyryl-3-amino-4-methoxybenzyisulfone (10 mmol) in tetrahydrofuran. The solution is stirred overnight and the reaction progress is monitored by TLC. The solvent is removed and the residue is taken up in dichloromethane and washed with water. The organic layer is dried over anhydrous sodium sulfate and evaporated to give the desired amide product.

Workup

  1. customThe solvent is removed
  2. washwashed with water
  3. dry with materialThe organic layer is dried over anhydrous sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-c39599c362fc4905a3a1f25511e716d7
Source dataset
uspto-grants-2009_10
Patent number
US07598232B2

Reaction notes

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