反应详情

A solution of N-(3,4-dimethoxybenzyl)-7-(2-fluorobenzyl)-4-(2-furyl)-7H-pyrrolo[2,3-d]pyrimidine-2-amine (110 mg, 0.24 mmol) in TFA (1 mL) was heated to 50° C. for 3 h, concentrated in vacuo, treated with saturated NaHCO3, extracted with EtOAc, dried (MgSO4), concentrated in vacuo, purified by chromatography (EtOAc:Heptane, 1:4) and recrystallised (EtOAc) to give the title compound (38 mg, 51%) as a cream solid.

1. concentrationconcentrated in vacuo
2. additiontreated with saturated NaHCO3
3. extractionextracted with EtOAc
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo
6. custompurified by chromatography (EtOAc:Heptane, 1:4)
7. customrecrystallised (EtOAc)