1-Bromo-3,6-dioxaheptane → HCID 11691586, compound

HRID 1817221Notes

Reaction equation

HRID 1817221 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:10]#[N:11])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH3:31]>>[Br-:24].[C:10]([C:9]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH3:31])([CH2:2][CH2:3]1)[CH2:8][CH2:7]2)#[N:11]

Participants

3

Reactant 2

HCID 1235321-Bromo-3,6-dioxaheptaneHCID 11716432HCID 11716432, compound

Product 1

HCID 11691586HCID 11691586, compoundYield 54.6%

Procedure

Following the general procedure outlined in Example 7, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)acetonitrile (0.0495 g, 0.164 mmol) and 1-bromo-2-{[2-(methyloxy)ethyl]oxy}ethane (0.040 mL, 0.265 mmol) in 2CH3CN/3CHCl3 (4.0 mL) were reacted to give the desired product (0.0431 g, 54.6%). EI-MS m/z 405 (M+) Rt (1.85 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ec1b4a6113774d8aac102fdc6dae81d8
Source dataset
uspto-grants-2009_10
Patent number
US07598267B2

Reaction notes

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