HCID 16102059, compound → 2-Amino-5-(4-methyl-1-piperazinyl)benzonitrile

HRID 1817230Notes

Reaction equation

HRID 1817230 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[CH:10][C:11]([N+:16]([O-])=O)=[C:12]([C:14]#[N:15])[CH:13]=2)[CH2:4][CH2:3]1>CCOC(C)=O.[Pd]>[NH2:16][C:11]1[CH:10]=[CH:9][C:8]([N:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:13][C:12]=1[C:14]#[N:15]

Participants

4

Reactant 1

HCID 16102059HCID 16102059, compound

Product 1

HCID 219285192-Amino-5-(4-methyl-1-piperazinyl)benzonitrile

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

5-(4-Methylpiperazinyl)-2-nitrobenzenecarbonitrile (1.0 eq) was dissolved in EtOAc. The flask was purged with nitrogen, and 10% Pd/C (0.1 eq) was added. The flask was evacuated and purged with H2 three times. The resulting mixture was stirred for three days at room temperature. The mixture was filtered through Celite and the filter pad was washed with EtOAc. The solvent was removed in vacuo to give a yellow solid which was purified by silica gel chromatography (5:1:95 MeOH:Et3N:EtOAc) to give the desired product as a yellow solid. LC/MS m/z 217.3 (MH+), Rt 0.95 minutes.

Workup

  1. additionwas added
  2. customThe flask was evacuated
  3. custompurged with H2 three times
  4. filtrationThe mixture was filtered through Celite
  5. washthe filter pad was washed with EtOAc
  6. customThe solvent was removed in vacuo
  7. customto give a yellow solid which
  8. customwas purified by silica gel chromatography (5:1:95 MeOH:Et3N:EtOAc)

Sources & evidence

ORD record
ord-386595436cb54fd29e8dd5058aacdcdd
Source dataset
uspto-grants-2009_10
Patent number
US07598268B2

Reaction notes

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