Hydrochloric Acid → HCID 178506097, compound

HRID 1817487Notes

Reaction equation

HRID 1817487 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][N:9]=[CH:8]2.[Br:14]Br.Cl>[OH-].[Na+]>[Br:14][C:8]1[C:7]2[C:11](=[C:3]([C:2]([F:1])([F:12])[F:13])[CH:4]=[CH:5][CH:6]=2)[NH:10][N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24408BromineHCID 203239087-(Trifluoromethyl)-1H-indazole

Product 1

HCID 178506097HCID 178506097, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a mechanically stirred solution of 7-trifluoromethyl-indazole (3.5 g, 18.8 mmol) in 20% NaOH was added bromine (0.62 mL, 12.1 mmol) dropwise. After stirring at ambient temperature for 2 hours, the reaction mixture was cooled and acidified to pH 6-7 by careful addition of concentrated HCl. The solids formed were filtered and dried to give the title compound (2.9 g) as a white solid.

Workup

  1. temperaturethe reaction mixture was cooled
  2. customThe solids formed
  3. filtrationwere filtered
  4. customdried

Sources & evidence

ORD record
ord-81267eba2eba4bcb9e31dfabc26076fa
Source dataset
uspto-grants-2009_10
Patent number
US07598286B2

Reaction notes

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