HCID 69058487, compound → HCID 11687913, compound

HRID 1817493Notes

Reaction equation

HRID 1817493 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:15]([C:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]([CH:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[N:18]=2)O)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[Pd].C(O)C.C1CCCCC=1>[CH:26]1([N:19]2[C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:17]([CH2:15][C:11]3[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][CH:12]=3)=[N:18]2)[CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

4

Reactant 1

HCID 69058487HCID 69058487, compound

Product 1

HCID 11687913HCID 11687913, compoundYield 484.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 18676862Cyclohexene ethanolSolvent

Procedure

A mixture of [3-(benzyloxy)phenyl](1-cyclopentyl-1H-indazol-3-yl)methanol (0.24 g, 0.6 mmol) and 10% palladium on carbon in ethanol/cyclohexene (3:1, v/v) was heated at reflux for 1 hour. The catalyst was filtered (celite) and the filtrate concentrated in vacuo to give 0.85 g of product as a white solid.

Workup

  1. temperaturev/v) was heated
  2. temperatureat reflux for 1 hour
  3. filtrationThe catalyst was filtered (celite)
  4. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-0bee4c5bfd8e49acad8957aacf5b6f1f
Source dataset
uspto-grants-2009_10
Patent number
US07598286B2

Reaction notes

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