Lithium Hydroxide → HCID 59639976, compound

HRID 1817695Notes

Reaction equation

HRID 1817695 reaction equation
[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][CH2:18]/[CH:19]=[CH:20]/[C:21]2[CH:26]=[CH:25][C:24]([O:27][S:28]([CH3:31])(=[O:30])=[O:29])=[CH:23][CH:22]=2)=[CH:13][CH:12]=1)[C:5]([O:7]CC)=[O:6])[CH3:2].[OH-].[Li+]>CO.C1COCC1.O>[CH2:1]([O:3][C@@H:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH:17][CH2:18]/[CH:19]=[CH:20]/[C:21]2[CH:22]=[CH:23][C:24]([O:27][S:28]([CH3:31])(=[O:29])=[O:30])=[CH:25][CH:26]=2)=[CH:15][CH:16]=1)[C:5]([OH:7])=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 10173705HCID 10173705, compound

Product 1

HCID 59639976HCID 59639976, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

The title compound was synthesized by hydrolyzing ethyl 2-ethoxy-3-{4-[(E)-3-(4-methylsulfonyloxyphenyl)-2-propenylamino]-phenyl}propionate obtained in Example 12 (4 g, 8.95 mmol) in methanol-THF-water (45:4:9, 58 mL) using lithium hydroxide (563 mg, 13.42 mmol) following the same procedure as described in the Example 14 (1.2 g, 32%).

Sources & evidence

ORD record
ord-3b2d0472c7674a9baf0d73feee1c7fdf
Source dataset
uspto-grants-2009_10
Patent number
US07598293B2

Reaction notes

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