HCID 10238002, compound → HCID 178467706, compound

HRID 1817697Notes

Reaction equation

HRID 1817697 reaction equation
[CH2:1]([O:3][CH:4]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][S:26]([CH3:29])(=[O:28])=[O:27])=[CH:21][CH:20]=2)=[CH:11][CH:10]=1)[C:5]([OH:7])=[O:6])[CH3:2].[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:38])[NH2:37]>CO>[NH2:30][C@H:31]([C:39]([OH:41])=[O:40])[CH2:32][CH2:33][CH2:34][NH:35][C:36](=[NH:37])[NH2:38].[CH2:1]([O:3][CH:4]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([NH:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][C:22]([O:25][S:26]([CH3:29])(=[O:27])=[O:28])=[CH:23][CH:24]=2)=[CH:13][CH:14]=1)[C:5]([OH:7])=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 10238002HCID 10238002, compoundHCID 178418600HCID 178418600, compound

Product 1

HCID 178467706HCID 178467706, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Ethoxy-3-[4-{3-(4-methanesulfonyloxyphenyl)propylamino}phenyl]propionic acid (100 mg, 1 eq, 0.237 mmol) obtained in Example 15 and L-arginine (41.2 mg, 1 eq, 0.237 mmol) were taken in dry methanol (3 ml), and stirred at RT for 2-3 h. The solvent was removed on rotavapour followed by benzene azeotrope. The residue was dried under high vacuum pump to yield the title compound as a free flowing solid (yield 100%).

Workup

  1. customThe solvent was removed on rotavapour
  2. customThe residue was dried under high vacuum pump

Sources & evidence

ORD record
ord-a771cad2341e47a3b0d009f7c93cab68
Source dataset
uspto-grants-2009_10
Patent number
US07598293B2

Reaction notes

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