HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-[3-(5-Methyl-2-m-tolyloxazol-4-ylmethoxymethyl)cyclohexylcarbamoyl]cyclobutanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (1R,5S)-3-Oxabicyclo[3.2.0]heptane-2,4-dione | HCID 11400767 | — |
| Reactant | 3-(5-Methyl-2-m-tolyloxazol-4-ylmethoxymethyl)cyclohexylamine | HCID 57882732 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[3-(5-Methyl-2-m-tolyloxazol-4-ylmethoxymethyl)cyclohexylcarbamoyl]cyclobutanecarboxylic acid | HCID 11561257 | 51.4% |
Reaction Steps
50 mg of 3-(5-methyl-2-m-tolyloxazol-4-ylmethoxymethyl)cyclohexylamine were dissolved in 0.97 ml of DMF, and 32 mg of triethylamine were added. 22 mg of cis-cyclobutane-1,2-dicarboxylic anhydride were then added, and the solution was stirred at RT overnight. The solution was purified directly by HPLC, which gave 36 mg of 2-[3-(5-methyl-2-m-tolyloxazol-4-ylmethoxymethyl)cyclohexylcarbamoyl]cyclobutanecarboxylic acid. C25H32N2O5 (440.54), MS (ESI): 441 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598281B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-25f5765f53b54b11bd1a44cb11691c36 |
| Source note | uspto-grants-2009_10 |