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HRID1817747

反应详情

EQUATION

反应方程式

HRID 1817747 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：O=C1OC(=O)[C@@H]2CC[C@H]12
HCID11400767

未命名化合物

结构：Cc1cccc(-c2nc(COCC3CCCC(N)C3)c(C)o2)c1
HCID57882732

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cccc(-c2nc(COCC3CCCC(NC(=O)C4CCC4C(=O)O)C3)c(C)o2)c1
HCID11561257

未命名化合物

收率 51.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

50 mg of 3-(5-methyl-2-m-tolyloxazol-4-ylmethoxymethyl)cyclohexylamine were dissolved in 0.97 ml of DMF, and 32 mg of triethylamine were added. 22 mg of cis-cyclobutane-1,2-dicarboxylic anhydride were then added, and the solution was stirred at RT overnight. The solution was purified directly by HPLC, which gave 36 mg of 2-[3-(5-methyl-2-m-tolyloxazol-4-ylmethoxymethyl)cyclohexylcarbamoyl]cyclobutanecarboxylic acid. C25H32N2O5 (440.54), MS (ESI): 441 (MH+).

WORKUP

后处理

  1. customThe solution was purified directly by HPLC, which