1,3-Cyclohexanedione → 5-Oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

HRID 1817796Notes

Reaction equation

HRID 1817796 reaction equation
C1(=O)CCCC(=O)C1.C[C:10]1(C)[CH2:19][C:18]2[NH:17][C:16](=[S:20])[C:15]([C:21]#[N:22])=[CH:14][C:13]=2[C:12](=[O:23])[CH2:11]1>>[O:23]=[C:12]1[CH2:11][CH2:10][CH2:19][C:18]2[NH:17][C:16](=[S:20])[C:15]([C:21]#[N:22])=[CH:14][C:13]1=2

Participants

3

Reactant 2

HCID 104341,3-CyclohexanedioneHCID 19346807,7-Dimethyl-5-oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

Product 1

HCID 18499675-Oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrileYield 52%

Procedure

Prepared in 52% yield from cyclohexane-1,3-dione in analogy to the procedure described for 7,7-dimethyl-5-oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile synthesis.

Sources & evidence

ORD record
ord-f653c2b90143492fb7bc658c11944c46
Source dataset
uspto-grants-2009_10
Patent number
US07598384B2

Reaction notes

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