1-Bromopropane → 7,7-Dimethyl-5-oxo-2-propylsulfanyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile

HRID 1817813Notes

Reaction equation

HRID 1817813 reaction equation
[CH3:1][C:2]1([CH3:16])[CH2:11][C:10]2[NH:9][C:8](=[S:12])[C:7]([C:13]#[N:14])=[CH:6][C:5]=2[C:4](=[O:15])[CH2:3]1.Br[CH2:18][CH2:19][CH3:20]>>[CH3:1][C:2]1([CH3:16])[CH2:11][C:10]2[N:9]=[C:8]([S:12][CH2:18][CH2:19][CH3:20])[C:7]([C:13]#[N:14])=[CH:6][C:5]=2[C:4](=[O:15])[CH2:3]1

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 19346807,7-Dimethyl-5-oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

Product 1

HCID 578833077,7-Dimethyl-5-oxo-2-propylsulfanyl-5,6,7,8-tetrahydroquinoline-3-carbonitrileYield 91%

Procedure

In analogy to the procedure described in Example 1, 7,7-dimethyl-5-oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile was treated with 1-bromopropane to give the title compound in 91% yield.

Sources & evidence

ORD record
ord-576a37b7e11243babcb0bb4d229931e0
Source dataset
uspto-grants-2009_10
Patent number
US07598384B2

Reaction notes

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