2-Cyclopropylacetyl chloride → 1,2-bis(Cyclopropylmethyl)-5-(isopropylsulfonyl)-1H-benzimidazole

HRID 1817857Notes

Reaction equation

HRID 1817857 reaction equation
[CH:1]1([CH2:4][C:5](Cl)=O)[CH2:3][CH2:2]1.[NH2:8][C:9]1[CH:14]=[C:13]([S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=1[NH:21][CH2:22][CH:23]1[CH2:25][CH2:24]1>>[CH:23]1([CH2:22][N:21]2[C:10]3[CH:11]=[CH:12][C:13]([S:15]([CH:18]([CH3:20])[CH3:19])(=[O:17])=[O:16])=[CH:14][C:9]=3[N:8]=[C:5]2[CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 143262682-Cyclopropylacetyl chlorideHCID 688699912-Amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene

Product 1

HCID 578839851,2-bis(Cyclopropylmethyl)-5-(isopropylsulfonyl)-1H-benzimidazole

Procedure

The title compound was prepared according to the procedure described in Step C of Example 5 from cyclopropylacetyl chloride (Step A) and 2-amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene (Step E of Example 1).

Sources & evidence

ORD record
ord-2ee932ac5b2a456b89460443e5e4415c
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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