Hydrochloric Acid → HCID 68873780, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Step B of Example 1 using 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-[(isopropylthio)methyl]-1H-benzimidazole (Step F) instead of 1-chloro-4-(isopropylthio)benzene. Obtained 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-[(isopropylsulfonyl)methyl]-1H-benzimidazole was dissolved in ethyl acetate and to the solution was added 4 N hydrogen chloride in ethyl acetate. The precipitate was collected by filtration to afford the title compound as a white solid.

Provenance & Evidence