Hydrochloric Acid → HCID 68873780, compound

HRID 1817864Notes

Reaction equation

HRID 1817864 reaction equation
C1(CN2C3C=CC(CSC(C)C)=CC=3N=C2CC(C)(C)C)CC1.[CH:24]1([CH2:27][N:28]2[C:32]3[CH:33]=[CH:34][C:35]([CH2:37][S:38]([CH:41]([CH3:43])[CH3:42])(=[O:40])=[O:39])=[CH:36][C:31]=3[N:30]=[C:29]2[CH2:44][C:45]([CH3:48])([CH3:47])[CH3:46])[CH2:26][CH2:25]1.[ClH:49]>C(OCC)(=O)C>[ClH:49].[CH:24]1([CH2:27][N:28]2[C:32]3[CH:33]=[CH:34][C:35]([CH2:37][S:38]([CH:41]([CH3:42])[CH3:43])(=[O:39])=[O:40])=[CH:36][C:31]=3[N:30]=[C:29]2[CH2:44][C:45]([CH3:47])([CH3:46])[CH3:48])[CH2:26][CH2:25]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 57884009HCID 57884009, compoundHCID 68869725HCID 68869725, compound

Product 1

HCID 68873780HCID 68873780, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

The title compound was prepared according to the procedure described in Step B of Example 1 using 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-[(isopropylthio)methyl]-1H-benzimidazole (Step F) instead of 1-chloro-4-(isopropylthio)benzene. Obtained 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-[(isopropylsulfonyl)methyl]-1H-benzimidazole was dissolved in ethyl acetate and to the solution was added 4 N hydrogen chloride in ethyl acetate. The precipitate was collected by filtration to afford the title compound as a white solid.

Workup

  1. customThe title compound was prepared
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-9586f49d36ac4d1182b1c5384e13f3c0
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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