4-Aminomethyltetrahydropyran → 5-(Isopropylsulfonyl)-3-nitro-N-(tetrahydro-2H-pyran-4-ylmethyl)pyridin-2-amine

HRID 1817876Notes

Reaction equation

Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([CH:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])=[CH:4][N:3]=1.[NH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[CH:14]([S:11]([C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[N:3][CH:4]=1)(=[O:13])=[O:12])([CH3:16])[CH3:15]

Participants

Reactant 2

HCID 27732104-Aminomethyltetrahydropyran

HCID 862419792-Chloro-5-(isopropylsulfonyl)-3-nitropyridine

Product 1

HCID 688713665-(Isopropylsulfonyl)-3-nitro-N-(tetrahydro-2H-pyran-4-ylmethyl)pyridin-2-amine

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 2-chloro-5-(isopropylsulfonyl)-3-nitropyridine (Step D of Example 22) and 4-aminomethyltetrahydropyran (Apollo Scientific Ltd.).

Sources & evidence

ORD record: ord-1d07601dccef4141a9e52ee35acbd709
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598393B2

Reaction notes

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