Diisopropylethylamine → HCID 62897617, compound

HRID 1817901Notes

Reaction equation

HRID 1817901 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](F)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.Cl.[NH2:13][CH2:14][C:15]1([OH:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.C(N(CC)C(C)C)(C)C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:13][CH2:14][C:15]2([OH:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27363284-Bromo-1-fluoro-2-nitrobenzeneHCID 3084332Cyclohexanol, 1-(aminomethyl)-, hydrochloride (1:1)

Product 1

HCID 62897617HCID 62897617, compound

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 4-bromo-1-flouro-2-nitrobenzene (Wako Pure Chemical Industries, Ltd.), 1-(aminomethyl)cyclohexanol hydrochloride (J. Med. Chem. 1981, 24, 7-12.) and N,N-diisopropylethylamine.

Sources & evidence

ORD record
ord-b46e2d09490146bd97a5a2928bd4a088
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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