1-Fluoro-4-methanesulfonyl-2-nitrobenzene → 4-(Methylsulfonyl)-2-nitro-N-(tetrahydro-2H-Pyran-4-ylmethyl)aniline

HRID 1817905Notes

Reaction equation

F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[NH2:15][CH2:16][CH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>>[CH3:11][S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[C:3]([N+:12]([O-:14])=[O:13])[CH:4]=1)(=[O:10])=[O:9]

Participants

Reactant 2

HCID 3131371-Fluoro-4-methanesulfonyl-2-nitrobenzene

HCID 27732104-Aminomethyltetrahydropyran

Product 1

HCID 623510264-(Methylsulfonyl)-2-nitro-N-(tetrahydro-2H-Pyran-4-ylmethyl)aniline

Procedure

The title compound was prepared according to the procedure described in Step A of Example 5 from 1-fluoro-4-(methylsulfonyl)-2-nitrobenzene (Acros Organics Ltd.) and 4-aminomethyltetrahydropyran (Apollo Scientific Ltd.).

Sources & evidence

ORD record: ord-9760c4ecee1a4b9abc7191a16c5cf884
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598393B2

Reaction notes

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