HCID 66917789, compound → HCID 66917764, compound

HRID 1818004Notes

Reaction equation

HRID 1818004 reaction equation
C([O:8][C:9]1[C:14]2[N:15]([CH2:19][C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=3)[C:16]([CH3:18])=[N:17][C:13]=2[CH:12]=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.C(O)(=O)C.[Pd]>[CH3:18][CH:16]1[NH:17][C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([OH:8])[C:14]=2[N:15]1[CH2:19][C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=1

Participants

5

Reactant 1

HCID 66917789HCID 66917789, compound

Product 1

HCID 66917764HCID 66917764, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

7-Benzyloxy-2-methyl-1-naphthalen-2-ylmethyl-1H-benzoimidazole (211 mg) in methanol (12 mL) and acetic acid (1.0 mL) was hydrogenated in presence of 10% Pd—C at 45 psi for 20 h. Reaction mixture was filtered through a pad of celite. The filtrate was concentrated to afford 2-methyl-3-naphthalen-2-ylmethyl-1H-benzoimidazol-4-ol, I-111 (211 mg).

Workup

  1. customReaction mixture
  2. filtrationwas filtered through a pad of celite
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-612407150c004baaa946f753ae10cd97
Source dataset
uspto-grants-2009_10
Patent number
US07598397B2

Reaction notes

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