HCID 68879380, compound → 1071727-61-1

HRID 1818019Notes

Reaction equation

HRID 1818019 reaction equation
C[O:2][C:3]([CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[F:14])[CH2:6]1)=[O:4]>CC(O)=O>[F:14][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH2:13][CH:5]([C:3]([OH:4])=[O:2])[CH2:6]2

Participants

3

Reactant 1

HCID 68879380HCID 68879380, compound

Product 1

HCID 688780481071727-61-1

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4-Fluoro-indan-2-carboxylic acid methyl ester in HOAc containing 20% HCl was hydrolyzed according to the protocols as outlined in general procedure G to afford the desired title acid. Spectroscopic data: 1H NMR (300 MHz, DMSO-d6) δ 3.09-3.23 (m, 4H), 3.29-3.40 (m, 1H), 7.0 (t, 1H, J=8.5 Hz), 7.1 (d, 1H, J=7.3 Hz), 7.14-7.24 (m, 1H), 12.4 (br s, 1H).

Workup

  1. customto afford the desired title acid

Sources & evidence

ORD record
ord-d8beccfec4dc4e2e9e1336e8887e5666
Source dataset
uspto-grants-2009_10
Patent number
US07598417B2

Reaction notes

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