Hydrochloric Acid → Hexafluoroacetone monohydrate
Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]([C:8]([F:11])([F:10])[F:9])([OH:7])C([O-])=[O:5].[K+].Cl.C(=O)([O-])O.[K+].Cl[O-].[Na+]>>[OH2:5].[F:1][C:2]([F:13])([F:12])[C:3]([C:8]([F:11])([F:10])[F:9])=[O:7]Participants
5
Conditions
- Temperature
- 40 °C
Procedure
In a 100-ml three-necked flask was placed 6.52 g (14.8 mmol) of the 56.8% aqueous potassium 3,3,3-trifluoro-2-trifluoromethyl-2-hydroxypropionate solution prepared in Reference Example 1. To this mixture were added 1.7 g of 35% hydrochloric acid and 0.8 g of potassium hydrogencarbonate in this order, thereby adjusting the pH to 8. Subsequently, 24.0 g (32.3 mmol) of 10% aqueous sodium hypochlorite solution was added over one hour while heating the mixture at 40° C. in a water bath, followed by further stirring for 5 hours while maintaining the same temperature. The pH when the reaction was complete was 8. Hexafluoroacetone hydrate was obtained at a starting material conversion of 90% with a selectivity of at least 99%.
Workup
- customIn a 100-ml three-necked flask was placed
- temperaturewhile maintaining the same temperature
Sources & evidence
- ORD record
- ord-6bb9f60611af4ea6b0fac75052244c90
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07598425B2
Reaction notes
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